Expression of serum soluble Klotho protein in patients with renal damage induced by anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis and influence on prognosis

Abstract Background : Anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis (AASV) is an autoimmune disease with unclear pathogenesis, which causes damage to multiple organs and systems, renal failure or even death. We aimed explore the expression of serum soluble Klotho protein in patients AASV-induced influence on prognosis. Methods A total 330 AASV treated from June 2012 2014 were divided into non-renal groups. Clinical symptoms laboratory examination results compared. They <935.05 pg/mL ≥935.05 groups, pathological indices Survival curves plotted using Kaplan-Meier method, 5-year survival rates Results Compared group, mean arterial pressure, urine blood creatinine levels significantly rose, while red cell count, hemoglobin, albumin, declined group (P<0.05). The optimal cut-off value assessing was 935.05 pg/mL. increased, proportion normal glomeruli decreased, that fibrous crescents rose rate lower than Conclusions lowly expressed induced by as a potential marker for early diagnosis prognostic evaluation.